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Scientific studies behind the Sapiens diagnostics

Overview of peer-reviewed research behind the Sapiens diagnostics, including research on allostatic load, hair and saliva stress markers, as well as evidence for interventions.

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A new rating scale for adult resilience: what are the central protective resources behind healthy adjustment?

Stress Resilience
Methodological/validation
Medium
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Development and validation of the Resilience Scale for Adults (RSA), a 45-item measure of protective resources across five dimensions (personal/social competence, family coherence, social support, personal structure), tested in 59 patients and 276 controls with a four-month retest.

Biomarker Studies
Self-Assessment
Before 2015

Increased dopamine tone during meditation-induced change of consciousness

Intervention
Experimental/mechanistic
Medium
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A 11C-raclopride PET study measuring endogenous striatal dopamine release during Yoga Nidra meditation versus attending to speech, alongside EEG, in participants who reported reduced desire for action during meditation.

Intervention Studies
Before 2015

Attachment-style differences in the ability to suppress negative thoughts: Exploring the neural correlates

Stress Resilience
Cross-sectional
Medium
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fMRI study of 20 women who thought about and then tried to stop thinking about relationship scenarios, examining how attachment anxiety and avoidance relate to neural activation during emotion regulation. Correlated attachment dimensions with activity in emotion-related and regulatory brain regions.

Biomarker Studies
Before 2015

The measurement of effort–reward imbalance at work: European comparisons

Stress Resilience
Methodological/validation
Medium
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Using data from five European countries, this study evaluated the psychometric properties of the effort-reward imbalance work-stress model, testing internal consistency, factorial structure, and discriminant and content validity of the effort, reward, and overcommitment scales via confirmatory factor analysis, and relating them to self-reported health.

Biomarker Studies
Self-Assessment
Before 2015

The restorative benefits of nature: Toward an integrative framework

Cognition & Stress
Narrative review
Medium
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Conceptual paper presenting Attention Restoration Theory, analyzing how directed-attention fatigue and stress relate to human-environment interactions. Argues that natural environments are especially rich in the qualities that support restorative experiences.

Intervention Studies
Before 2015

Designing Exercise Regimens to Increase Bone Strength

Intervention
Narrative review
Medium
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Review of clinical and laboratory studies on how exercise strengthens bone, particularly during childhood and adolescence, deriving an 'osteogenic index' to quantify the bone-building effects of different exercise regimens.

Intervention Studies
Before 2015

Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being

Stress Resilience
Cross-sectional
Medium
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Series of five studies developing measures of the habitual use of two emotion-regulation strategies (reappraisal and suppression) and examining their implications for affect, well-being, and social relationships.

Biomarker Studies
Self-Assessment
Before 2015

The stress-eating paradox: Multiple daily measurements in adult males and females

Nutrition & Health
Longitudinal
Medium
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A prospective diary study in which 158 adults recorded daily stress and eating over 84 days (16,188 person-days), analyzed both within- and between-subjects. It examined how everyday stress relates to eating more versus eating less and gender differences therein.

Biomarker Studies
Self-Assessment
Before 2015

Basic Rest-Activity Cycle—22 Years Later

Sleep & Stress
Narrative review
Medium
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Review presenting data supporting the existence of an ultradian basic rest-activity cycle (BRAC) governed by the central nervous system, manifesting as alternating non-REM/REM sleep and a similar periodicity during wakefulness.

Biomarker Studies
Before 2015